Biological Psychiatry Current Evidence for the Role of Rapid-Acting Antidepressants (RAAD) in Bipolar Depression? A Perspective and Plan for Action Reviewing the potential of RAADs like ketamine and psilocybin for bipolar depression, highlighting current research and future directions.
Neuroscience Applied A Review of Psychedelics Trials Completed in Depression, Informed by European Regulatory Perspectives A systematic review of completed psychedelics trials for depression, highlighting key findings and regulatory challenges.
Clinical Pharmacology & Therapeutics Acute Effects and Pharmacokinetics of LSD after Paroxetine or Placebo Pre-Administration in a Randomized, Double-Blind, Cross-Over Phase I Trial A study examining the interaction of LSD and paroxetine finds reduced anxiety and nausea but unchanged pleasant effects. Paroxetine increases LSD levels via CYP2D6 inhibition.
Pharmacological Reviews Safety in Treatment: Classical Pharmacotherapeutics and New Avenues for Addressing Maternal Depression and Anxiety During Pregnancy This study examines the safety of antidepressant use during pregnancy, weighing the risks of untreated depression and exploring emerging treatment options.
Journal of Neurochemistry Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons A study on how psychedelics modulate glutamate release in cortical neurons, highlighting their potential for treating depression and enhancing neuroplasticity.
Cancer Medicine Psychedelics for Cancer Pain and Associated Psychological Distress: A Narrative Review of a Potential Strategy A review of psychedelics for cancer pain and distress, highlighting their potential role in reducing pain perception and improving mood.
Depression Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic This study aimed to evaluate the efficacy of psilocybin therapy in reducing symptoms of depression, burnout, and PTSD in frontline clinicians affected by the COVID-19 pandemic.
Psilocybin Into the Wild Frontier: Mapping the Terrain of Adverse Events in Psychedelic-Assisted Therapies This study aims to explore the risks associated with psychedelic-assisted therapies (PATs) by evaluating potential adverse events (AEs) to develop a comprehensive and standardized assessment framework.
Journal of Psychedelic Studies Client Treatment Preferences in Psychedelic-Assisted Therapy for Depression in Participants with Depressive Symptoms Study explores therapist demographic preferences in psychedelic therapy, highlighting the importance of race and gender for client comfort.
Journal of Psychedelic Studies Ketamine and Epigenetic Processes in Depression: Intersection Between Serotonergic and Glutamatergic Pathways This study explores ketamine’s role in treating depression through epigenetic modifications, linking serotonergic and glutamatergic pathways.
Psilocybin A Brief Review on the Potential of Psychedelics for Treating Alzheimer’s Disease and Related Depression This review investigates the potential role of psychedelics in addressing Alzheimer’s disease and associated depression, focusing on their neurochemical effects and therapeutic mechanisms.
